High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity
Rodrigo Vazquez-Lombardi, Johanna S. Jung, Fabrice S. Schlatter, Anna Mei, Natália Rodrigues Mantuano, Florian Bieberich, Kai‐Lin Hong, Jakub Kucharczyk, Edo Kapetanovic, Erik Aznauryan, Cédric R. Weber, Alfred Zippelius, Heinz Läubli, Sai T. Reddy
Topics & Concepts
T-cell receptorBiologyChimeric antigen receptorImmunotherapyComputational biologyAntigenT cellPotencyAdoptive cell transferMajor histocompatibility complexIn vitroCell biologyImmunologyImmune systemBiochemistryCAR-T cell therapy researchNanowire Synthesis and ApplicationsImmune Cell Function and Interaction