Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach
Sophia Mahoney, Nicholas S. VanDongen, Nathan Greenberg, Ravinandan Venkatasubramanian, Matthew J. Rossman, Michael E. Widlansky, Vienna E. Brunt, Yara Bernaldo de Quirós, Douglas R. Seals, Zachary S. Clayton
Abstract
Changes in the circulating milieu with advancing age may be a mechanism underlying age-related arterial dysfunction. Ex vivo exposure of young mouse arteries to the circulating milieu from old mice or midlife/older adults impairs arterial function whereas exposure of old mouse arteries to the circulating milieu from young mice or young adults improves arterial function. These findings establish that the circulating milieu directly influences arterial function with aging.
Topics & Concepts
Ex vivoIn vivoMedicineInternal medicineBiologyGeneticsCardiovascular Health and Disease PreventionThermoregulation and physiological responsesHeart Rate Variability and Autonomic Control