Protection against Reinfection with the Omicron BA.2.75 Subvariant
Hiam Chemaitelly, Patrick Tang, Peter Coyle, Hadi M. Yassine, Hebah A. Al-Khatib, Maria K. Smatti, Mohammad R. Hasan, Houssein H. Ayoub, Heba Altarawneh, Zaina Al Kanaani, Einas Al‐Kuwari, Andrew Jeremijenko, Anvar Hassan Kaleeckal, Ali Nizar Latif, Riyazuddin Mohammad Shaik, Hanan F. Abdul Rahim, Gheyath K. Nasrallah, Mohamed Ghaith Al‐Kuwari, Adeel A. Butt, Hamad Eid Al‐Romaihi, Mohamed H. Al‐Thani, Abdullatif Al‐Khal, Roberto Bertollini, Laith J. Abu‐Raddad
Abstract
Protection against Reinfection with the Omicron BA.2.75 Subvariant To the Editor: The BA.2.75 sublineage of the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may escape neutralizing antibodies. The BA.2.75 sublineage (primarily the BA.2.75.2 subvariant) became the predominant sublineage in Qatar by September 10, 2022 (Section S1 and Fig. S1 in the Supplementary Appendix, available with the full text of this letter at NEJM.org). We estimated the effectiveness of previous infection with SARS-CoV-2 in preventing reinfection with BA.2.75 using a test-negative, case-control study design (Section S2). 1