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<i>Panax notoginseng</i> saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction <i>via</i> leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity

Yu Xu, Ning Wang, Hor‐Yue Tan, Sha Li, Cheng Zhang, Zhang‐Jin Zhang, Yibin Feng

2020Theranostics171 citationsDOIOpen Access PDF

Abstract

: Our results revealed that leptin signaling is critical for alterations in microbiota-fat crosstalk and provide promising avenues for therapeutic intervention in the treatment of obesity.

Topics & Concepts

ThermogenesisGut floraBiologyWhite adipose tissueBrown adipose tissueAdipocyteLeptinEndocrinologyInternal medicineThermogeninFGF21AMPKAdipose tissueCell biologyImmunologyMedicineObesityBiochemistryProtein kinase AReceptorFibroblast growth factorPhosphorylationGut microbiota and healthAdipose Tissue and MetabolismGinseng Biological Effects and Applications