Curcumin loaded on graphene nanosheets induced cell death in mammospheres from MCF-7 and primary breast tumor cells
Saeideh Jafarinejad‐Farsangi, Mahnaz Sadat Hashemi, Seyede Elmira Yazdi Rouholamini, Sedigheh Gharbi, Zeinab Ansari‐Asl, Elham Jafari, Amin Shiralizadeh Dezfuli, Mariam Shahrokhi-Farjah
Abstract
< 0.0001). Also, the expression pattern of miR-21, miR-29a, and Bax/Bcl-2 ratio in KMBC/71 and MCF-7 mammospheres was different in response to GO-Cur and GQDs-Cur. Although KMBC/71 and MCF-7 tumor cells had similar clinical features and displayed similar responses to curcumin, more investigations are needed to clarify the detailed molecular mechanisms underlying observed differences in response to GO-Cur and GQDs-Cur.
Topics & Concepts
CurcuminMCF-7Propidium iodideCancer researchProgrammed cell deathFlow cytometryGrapheneApoptosisMaterials scienceCancer cellMedicineNanotechnologyCancerChemistryPharmacologyImmunologyBiochemistryHuman breastInternal medicineGraphene and Nanomaterials ApplicationsCarbon and Quantum Dots ApplicationsHeavy Metal Exposure and Toxicity