Facile One-Pot Synthesis of Meteor Hammer-like Au-MnO<sub><i>x</i></sub> Nanozymes with Spiky Surface for NIR-II Light-Enhanced Bacterial Elimination
Xiaonan Li, Si-Man Luo, Yu Chen, Yu‐Cheng Zuo, Yue Huang, Hong Zhang, Liheng Chen, Jun Feng, Jingyi Zhu, Wei Xue
Abstract
Inspired by the effective interfacial interactions between natural creatures (e.g., cockleburs and viruses) and their bio-hosts, we developed a novel gold-manganese oxide nanoparticle (Au-MnOx) nanoenzyme with a spiky surface for NIR-II light-induced synergistic antibacterial therapy. Au-MnOx with favorable photothermal performance and peroxidase-like activity could achieve combined photothermal therapy (PTT)/chemodynamic therapy (CDT) under NIR-II irradiation with a low concentration. Of special note, the spiky surface endows Au-MnOx robust bacterial adhesion, in turn favoring the following synergistic PTT/CDT through effective interaction between Au-MnOx and bacteria. In vitro results display that our combined antibacterial nanoplatforms possess the broad-spectrum antibacterial ability against both Escherichia coli (E. coli, Gram-negative) and Staphylococcus aureus (S. aureus, Gram-positive). Moreover, satisfactory in vivo bactericidal efficacy and good cytocompatibility could be obtained in the rat wound model with the mixed bacterial infections. This study puts forward a facile one-pot method to establish the well-designed Au-MnOx nanozymes with a spiky surface for NIR-II light-enhanced bacterial elimination. The meteor hammer-like Au-MnOx holds great potential in construction of a novel antibacterial treatment system to settle the overuse of antibiotics.