Renal organoid modeling of tuberous sclerosis complex reveals lesion features arise from diverse developmental processes
Adam Pietrobon, Julien Yockell‐Lelièvre, Trevor A. Flood, William L. Stanford
Abstract
Schwann cell precursors. Together, these results illustrate the pleiotropic developmental consequences of biallelic inactivation of TSC1 or TSC2 and offer insight into TSC kidney lesion pathogenesis.
Topics & Concepts
TSC1Tuberous sclerosisTSC2OrganoidBiologyCancer researchPathologyCell biologyMedicinePI3K/AKT/mTOR pathwaySignal transductionTuberous Sclerosis Complex ResearchRenal and related cancersRenal cell carcinoma treatment