De novo design of tyrosine and serine kinase-driven protein switches
Nicholas B. Woodall, Zara Y. Weinberg, Jesslyn Park, Florian Büsch, Richard S. Johnson, Mikayla J. Feldbauer, Michael Murphy, Maggie Ahlrichs, Issa Yousif, Michael J. MacCoss, Vicki H. Wysocki, Hana El‐Samad, David Baker
Topics & Concepts
SerineProtein-Tyrosine KinasesCell biologyTyrosineTyrosine kinaseChemistryReceptor tyrosine kinaseBiochemistryBiologyKinaseSignal transductionPhosphorylationUbiquitin and proteasome pathwaysProtein Kinase Regulation and GTPase SignalingComputational Drug Discovery Methods