Basic immunohistochemistry for lymphoma diagnosis
Junhun Cho
Abstract
) can be detected by the overexpression of Bcl-2 and cyclin D-1 in immunohistochemistry, respectively. Ki-67 reflects the degree of tumor cell proliferation by indicating cells in cell cycle phases other than G0. With the development of immunotherapy, several antibodies against markers such as programmed death-ligand 1 (PD-L1), CD19, and CD30 have been used as biomarkers to identify therapeutic targets. It is critical to properly fix the specimens to obtain accurate immunohistochemical results. Therefore, all processes, from tissue collection to the final pathological diagnosis, must be performed appropriately for accurate lymphoma diagnosis.
Topics & Concepts
CD30LymphomaMantle cell lymphomaCD20Anaplastic large-cell lymphomaImmunohistochemistryMedicinePathologyFollicular lymphomaCancer researchCyclin D1ImmunophenotypingAntigenImmunologyCell cycleInternal medicineCancerLymphoma Diagnosis and TreatmentCutaneous lymphoproliferative disorders researchCNS Lymphoma Diagnosis and Treatment