Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways
Wenqi Dong, Yumeng Jiang, Qingxiu Yao, Maoxiang Xu, Yuchen Jin, Lingkang Dong, Zhuangzhuang Li, Dongzhen Yu
Topics & Concepts
OtotoxicityCisplatinReactive oxygen speciesMAPK/ERK pathwayMitochondrionOxidative stressApoptosisPI3K/AKT/mTOR pathwayCell biologyBiologyMitochondrial ROSCell culturePharmacologyChemistryCancer researchSignal transductionBiochemistryGeneticsChemotherapyGenomics, phytochemicals, and oxidative stressMetalloenzymes and iron-sulfur proteinsGlutathione Transferases and Polymorphisms