Water Mediated Direct Thioamidation of Aldehydes at Room Temperature
Ankush Gupta, Jigarkumar K. Vankar, Jaydeepbhai P. Jadav, Guddeangadi N. Gururaja
Abstract
A mild, greener approach toward thioamide synthesis has been developed. Its unique features include water-mediated reaction with no input energy, additives, or catalysts as well. The presented protocol is attractive with readily available starting materials and the use of different array amines, along with a scaled-up method. Biologically active molecules such as thionicotinamide and thioisonicotinamide can be synthesized from this procedure.
Topics & Concepts
CatalysisThioamideMoleculeChemistryCombinatorial chemistryNanotechnologyChemical engineeringMaterials scienceOrganic chemistryEngineeringSynthesis and Reactivity of Sulfur-Containing CompoundsSynthesis of heterocyclic compoundsAdvanced Synthetic Organic Chemistry