Laser-Induced µ-Rooms for Osteocytes on Implant Surface: An In Vivo Study
Vadim P. Veiko, Yuliya Karlagina, Ekaterina Zernitckaia, Elena Egorova, Maxim Radaev, A.I. Yaremenko, Gennadiy Chernenko, В. В. Романов, Nadezhda Shchedrina, Elena P. Ivanova, Boris N. Chichkov, Galina Odintsova
Abstract
Laser processing of dental implant surfaces is becoming a more widespread replacement for classical techniques due to its undeniable advantages, including control of oxide formation and structure and surface relief at the microscale. Thus, using a laser, we created several biomimetic topographies of various shapes on the surface of titanium screw-shaped implants to research their success and survival rates. A distinctive feature of the topographies is the presence of "µ-rooms", which are special spaces created by the depressions and elevations and are analogous to the µ-sized room in which the osteocyte will potentially live. We conducted the comparable in vivo study using dental implants with continuous (G-topography with µ-canals), discrete (S-topography with μ-cavities), and irregular (I-topography) laser-induced topographies. A histological analysis performed with the statistical method (with p-value less than 0.05) was conducted, which showed that G-topography had the highest BIC parameter and contained the highest number of mature osteocytes, indicating the best secondary stability and osseointegration.