Urethanes synthesis from oxamic acids under electrochemical conditions
Ikechukwu Martin Ogbu, Jonathan Lusseau, Gülbin Kurtay, Frédéric Robert, Yannick Landais
Abstract
Urethane synthesis via oxidative decarboxylation of oxamic acids under mild electrochemical conditions is reported. This simple phosgene-free route to urethanes involves an in situ generation of isocyanates by anodic oxidation of oxamic acids in an alcoholic medium. The reaction is applicable to a wide range of oxamic acids, including chiral ones, and alcohols furnishing the desired urethanes in a one-pot process without the use of a chemical oxidant.
Topics & Concepts
DecarboxylationElectrochemistryChemistryOrganic chemistryCombinatorial chemistryElectrodeCatalysisPhysical chemistryRadical Photochemical ReactionsCO2 Reduction Techniques and CatalystsSulfur-Based Synthesis Techniques