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Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

Chris J. Frangieh, Johannes C. Melms, Pratiksha I. Thakore, Kathryn R. Geiger-Schuller, Patricia Ho, Adrienne Luoma, Brian Cleary, Livnat Jerby-Arnon, Shruti Malu, Michael S. Cuoco, Maryann Zhao, Casey R. Ager, Meri Rogava, Lila Hovey, Asaf Rotem, Chantale Bernatchez, Kai W. Wucherpfennig, Bruce E. Johnson, Orit Rozenblatt–Rosen, Dirk Schadendorf, Aviv Regev, Benjamin Izar

2021Nature Genetics270 citationsDOIOpen Access PDF

Topics & Concepts

BiologyEvasion (ethics)Immune systemCancerComputational biologyGeneticsSingle-cell and spatial transcriptomicsCAR-T cell therapy researchCancer Immunotherapy and Biomarkers
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion | Litcius