Structures and functions of the gut microbial lipidome
Satoshi Morozumi, Masahiro Ueda, Nobuyuki Okahashi, Makoto Arita
2022Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids19 citationsDOIOpen Access PDF
Abstract
Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.
Topics & Concepts
LipidomeLipidomicsBiologyComputational biologyGut floraLipid signalingReceptorBioinformaticsBiochemistryGut microbiota and healthMetabolomics and Mass Spectrometry StudiesProbiotics and Fermented Foods