Synthesis and structure–activity relationships of ticlopidine derivatives and analogs as inhibitors of ectonucleotidase CD39
Chunyang Bi, Laura Schäkel, Salahuddin Mirza, Katharina Sylvester, Julie Pelletier, Sang-Yong Lee, Thanigaimalai Pillaiyar, Jean Sévigny, Christa E. Müller
Topics & Concepts
ChemistryPurinergic receptorTiclopidineAllosteric regulationAdenosineNucleosideATP hydrolysisStereochemistryBiochemistryEnzymeClopidogrelAspirinATPaseAdenosine and Purinergic SignalingAdolescent and Pediatric HealthcareGenetics and Neurodevelopmental Disorders