Litcius/Paper detail

Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state

Daniela Cerezo‐Wallis, Marta Contreras-Alcalde, Kevin Troulé, Xavier Catena, Cynthia Mucientes, Tonantzin G. Calvo, Estela Cañón, Cristina Tejedo, Paula Comune Pennacchi, Sabrina A. Hogan, Peter Kölblinger, Héctor Tejero, Andrew Chen, Nuria Ibarz, Osvaldo Graña‐Castro, Lola Martínez, Javier Muñoz, Pablo L. Ortiz‐Romero, José Luis Rodríguez‐­Peralto, Gonzalo Goméz-López, Fátima Al‐Shahrour, Raúl Rabadán, Mitchell P. Levesque, David Olmeda, Marı́a S. Soengas

2020Nature Medicine178 citationsDOI

Topics & Concepts

MidkineTumor microenvironmentImmune checkpointImmune systemMelanomaCancer researchParacrine signallingAutocrine signallingDownregulation and upregulationImmunotherapyImmunologyNivolumabLymphokineMedicineBiologyGrowth factorInternal medicineReceptorBiochemistryGeneImmunotherapy and Immune ResponsesProteoglycans and glycosaminoglycans researchChemokine receptors and signaling