<i>Lactobacillus reuteri</i> JCM 1112 ameliorates chronic acrylamide-induced glucose metabolism disorder <i>via</i> the bile acid–TGR5–GLP-1 axis and modulates intestinal oxidative stress in mice
Zonghao Yue, Feiyue Zhao, Yuqi Guo, Yidan Zhang, Yanjuan Chen, Le He, Lili Li
Abstract
significantly enhanced ileal superoxide dismutase and catalase activities and total antioxidant capacity, thereby preventing chronic AA-induced oxidative stress. Our research provides new insights into the GMD toxicity of chronic low-dose AA and confirms the role of probiotics in alleviating AA-induced GMD.
Topics & Concepts
Lactobacillus reuteriG protein-coupled bile acid receptorOxidative stressChemistryOxidative metabolismMetabolismAcrylamideBile acidBiochemistryLactobacillusPharmacologyBiologyPolymerCopolymerOrganic chemistryFermentationPotato Plant ResearchDiet, Metabolism, and DiseasePhytoestrogen effects and research