Structures of Foot-and-Mouth Disease Virus with Bovine Neutralizing Antibodies Reveal the Determinant of Intraserotype Cross-Neutralization
Yong He, Kun Li, Li Wang, Zixian Sun, Yimei Cao, Pinghua Li, Pu Sun, Huifang Bao, Shasha Zhou, Sheng Wang, Xingwen Bai, Xuerong Liu, Lixia Zhao, Xiuli Fan, Zaixin Liu, Zengjun Lu, Cheng Yang, Zhiyong Lou
Abstract
Foot-and-mouth disease virus (FMDV) causes a highly contagious and economically devastating disease in cloven-hoofed animals, and neutralizing antibodies play critical roles in the defense against viral infections. Here, we isolated a bovine antibody (R55) using the single B cell antibody isolation technique.
Topics & Concepts
CapsidBiologyVirologyVirusNeutralizing antibodyPentamerNeutralizationAntibodyEpitopeViral proteinBinding sitePeptide sequenceProtein structureViral life cycleVero cellGenomeMutationGeneticsAmino acidProtein subunitViral entryHeterologousAntigenic variationMutantEpitope mappingAnimal Disease Management and EpidemiologyViral Infections and Immunology ResearchAnimal Virus Infections Studies