Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study
Alaa A.‐M. Abdel‐Aziz, Adel S. El‐Azab, Nawaf A. Alsaif, Ahmad J. Obaidullah, Abdulrahman M. Al‐Obaid, Ibrahim A. Al-Suwaidan
Abstract
into the binding sites of COX-2, EGFR, and HER2 were carried out to explore the interaction mode and the structural requirements for antitumor activity.
Topics & Concepts
PharmacophoreChemistryHydrazoneDocking (animal)IC50StereochemistryStructure–activity relationshipScaffoldActive siteCombinatorial chemistryCytotoxicityIn vitroEnzymeBiochemistryBiomedical engineeringMedicineNursingSynthesis and biological activitySynthesis and Biological EvaluationCancer therapeutics and mechanisms