Copper‐Catalyzed [3+2] Annulation of Pyridinium Ylides with α‐CF <sub>3</sub> Ketones: Synthesis of Functionalized 2‐Fluoroindolizines
Shiming Shu, Leilei Wang, Leiyang Lv, Zhiping Li
Abstract
Abstract A copper‐catalyzed [3+2] annulation of the in situ generated pyridinium ylides with α‐CF 3 ketones was realized, in which α‐CF 3 ketones first acted as the synthetic equivalents of unstable fluoroalkynones. With this protocol, a series of functionalized 2‐fluoroindolizines were afforded in moderate to good yields under ambient conditions with air as the oxidant.
Topics & Concepts
AnnulationChemistryPyridiniumCatalysisCopperMedicinal chemistryKetoneOrganic chemistryCombinatorial chemistrySynthesis and Reactivity of HeterocyclesFluorine in Organic ChemistryCyclopropane Reaction Mechanisms