Negative feedback control of hypothalamic feeding circuits by the taste of food
Tara J. Aitken, Zhengya Liu, Truong Ly, Sarah Shehata, Nilla Sivakumar, Naymalis La Santa Medina, Lindsay Gray, Jingkun Zhang, Naz Dundar, Chris Barnes, Zachary A. Knight
Abstract
) are tuned to respond to sweet or fatty tastes and exhibit time-locked activation during feeding that is the mirror image of downstream AgRP cells. These findings reveal an unexpected role for taste in the negative feedback control of ingestion. They also reveal a mechanism by which AgRP neurons, which are the primary cells that drive hunger, are able to influence the moment-by-moment dynamics of food consumption.
Topics & Concepts
TasteNeuroscienceNegative feedbackBiological neural networkPsychologyFood intakeControl (management)Neuronal circuitsFeeding behaviorBiologyCommunicationEndocrinologyComputer scienceArtificial intelligencePhysicsQuantum mechanicsVoltageBiochemical Analysis and Sensing TechniquesOlfactory and Sensory Function StudiesRegulation of Appetite and Obesity