Phase I study of opaganib, an oral sphingosine kinase 2-specific inhibitor, in relapsed and/or refractory multiple myeloma
Yubin Kang, Pasupathi Sundaramoorthy, Cristina Gasparetto, Daniel Feinberg, Shengjun Fan, Gwynn D. Long, Emily A. Sellars, Anderson Garrett, Sascha A. Tuchman, Brandi Reeves, Zhiguo Li, Bei Liu, Besim Öğretmen, Lynn W. Maines, Vered Katz Ben-Yair, Charles D. Smith, Terry F. Plasse
Topics & Concepts
MedicineMultiple myelomaInternal medicinePharmacodynamicsAdverse effectPharmacokineticsNeutropeniaPharmacologyRefractory (planetary science)OncologyHematologyProteasome inhibitorChemotherapyPhysicsAstrobiologyMultiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsSphingolipid Metabolism and Signaling