Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa
Carlota Gudiol, Adaia Albasanz‐Puig, Júlia Laporte-Amargós, Natàlia Pallarés, Alberto Mussetti, Isabel Ruíz-Camps, Pedro Puerta‐Alcalde, Edson Abdala, Chiara Oltolini, Murat Akova, Miguel Montejo, Małgorzata Mikulska, Pilar Martín‐Dávila, Fabián Herrera, Oriol Gasch, Ľuboš Drgoňa, Hugo Manuel Paz Morales, Anne-Sophie Brunel, Estefanía García, Burcu Isler, Winfried V. Kern, Isabel Morales, Guillermo Maestro de la Calle, M. Montero, Souha S. Kanj, Oğuz Reşat Sıpahı, S. Calik, Ignacio Márquez-Gómez, Jorge I. Marín, Marisa Zenaide Ribeiro Gomes, Philipp Hemmatti, Rafael Araos, Maddalena Peghin, José Luís del Pozo, Lucrecia Yáñez, Robert Tilley, Adriana Manzur, Andrés Novo, Jordi Carratalà, for the IRONIC Study Group, Guillermo Cuervo, Francesc Escrihuela-Vidal, Fé Tubau, Cristian Tebé, Marisol Rodríguez Arias, Nieves Larrosa, Celia Cardozo, Carolina García‐Vidal, Ibrahim Karim-Yaqub, Raffaella Greco, Paola Cichero, Çağlayan Merve Ayaz, Roberto Céspedes, Leire López-Soria, Laura Magnasco, Jesús Fortün, Diego Torres, A. Corral Bote, Mateu Espasa, M. Montaguti, Pierre–Yves Bochud, Oriol Manuel, Salvador Tabares Carrasco, Josefina Serrano López, Hartmut Bertz, Siegbert Rieg, Marina de Cueto, Jesús Rodríguez‐Baño, Manuel Lizasoaín, José María Aguado, Juan Pablo Horcajada, Saeed El Zein, Jean-Francois Jabbour, Ayşe Uyan-Önal, Arzu Nazlı, Begoña Palop, Lina Clemencia Correa, Amanda Aparecida da Silva Machado, João Pedro Silva Tonhá, Georg Maschmeyer, José M. Munita, Matteo Bassetti, Nadia Castaldo, Paloma Sangro del Alcázar
Abstract
We aimed to assess the rate and predictive factors of bloodstream infection (BSI) due to multidrug-resistant (MDR) Pseudomonas aeruginosa in neutropenic cancer patients. We performed a multicenter, retrospective cohort study including oncohematological neutropenic patients with BSI due to P. aeruginosa conducted across 34 centers in 12 countries from January 2006 to May 2018. A mixed logistic regression model was used to estimate a model to predict the multidrug resistance of the causative pathogens.