Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy
Yan-Ruide Li, Yang Zhou, Kwang Gi Kim, Yanni Zhu, Feiyang Ma, Jiaji Yu, Yu-Chen Wang, Xianhui Chen, Zhe Li, Samuel Zeng, Xi Wang, Derek Lee, Josh Ku, Tasha Tsao, Christian Hardoy, Jie Huang, Donghui Cheng, Amélie Montel‐Hagen, Christopher S. Seet, Gay M. Crooks, Sarah Larson, Joshua Sasine, Xiaoyan Wang, Matteo Pellegrini, Antoni Ribas, Donald B. Kohn, Owen N. Witte, Pin Wang, Lili Yang
Abstract
HSC-iNKT cell products and lay a foundation for their translational and clinical development.
Topics & Concepts
ImmunogenicityImmunotherapyImmune systemCell therapyImmunologyCancer immunotherapyChimeric antigen receptorCancer researchBiologyAntigenCancer cellCancerStem cellHaematopoiesisCell biologyGeneticsImmune Cell Function and InteractionCAR-T cell therapy researchHematopoietic Stem Cell Transplantation