Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization
Hiroyuki Kato, Kaori Asamitsu, Wendi Sun, Shojiro Kitajima, Naoko Yoshizawa-Sugata, Takashi Okamoto, Hisao Masai, Lorenz Poellinger
Topics & Concepts
BiologyTetratricopeptideSubcellular localizationMutantDemethylaseCytoplasmCell biologySuppressorHistoneCancerCancer researchGeneticsGeneEpigenetics and DNA MethylationCancer-related gene regulationGenomics and Chromatin Dynamics