The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents
Yushi Tan, Jiabo Wang, Hong‐Yu Zhang, Yuecheng Zhang, Jiquan Zhao
Abstract
The modification of quinoxalin-2(1H)-ones via direct C-H bond functionalization has recently received widespread attention, due to the quinoxalin-2(1H)-one derivatives’ various biological activities and pharmaceutical properties. This mini review concentrates on the accomplishments of arylation, trifluoromethylation, alkylation and alkoxylation of quinoxalin-2(1H)-ones with hypervalent iodine(III) reagents as reaction partners or oxidants. The reaction conditions and mechanisms are compared and discussed in detail.
Topics & Concepts
Hypervalent moleculeSurface modificationReagentIodineChemistryAlkylationCombinatorial chemistryTrifluoromethylationChloroformMedicinal chemistryOrganic chemistryCatalysisAlkylPhysical chemistryTrifluoromethylOxidative Organic Chemistry ReactionsSynthesis and Biological EvaluationFluorine in Organic Chemistry