How to perform pulmonary vein isolation using a pentaspline pulsed field ablation system for treatment of atrial fibrillation
Patrick Badertscher, Sven Knecht, Raphaël Rosso, Philipp Krisai, David Spreen, Josip Katić, Jeanne du Fay de Lavallaz, Christian Sticherling, Michael Kühne
Abstract
One of the most significant recent advances in developing new technologies for the interventional treatment of atrial fibrillation (AF) has been the introduction of pulsed field ablation (PFA).1 PFA denaturizes myocardial cells by exposing them to a short and intense electric field, causing irreversible electroporation and subsequent cell death.2 The threshold for irreversible electroporation is tissue specific, allowing it to minimize complications during AF ablation encountered with thermal energy sources, such as atrioesophageal fistula and phrenic nerve palsy.
Topics & Concepts
MedicinePulmonary veinAtrial fibrillationAblationIsolation (microbiology)CardiologyInternal medicineCatheter ablationBioinformaticsBiologyAtrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac electrophysiology and arrhythmias