Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation
Chengsheng Wu, Taha Rakhshandehroo, Hiromi I. Wettersten, Alejandro D. Campos, Tami Von Schalscha, Shashi Jain, Ziqi Yu, Jiali Tan, Evangeline Mose, Betzaira G. Childers, Andrew M. Lowy, Sara M. Weis, David A. Cheresh
Topics & Concepts
Downregulation and upregulationFibronectinExtracellular matrixCancer cellPancreatic cancerCell biologyLysophosphatidic acidCancer researchBiologyCancerReceptorBiochemistryGeneticsGeneProtein Degradation and InhibitorsPhagocytosis and Immune RegulationSphingolipid Metabolism and Signaling