Cytotoxic Effects of Verbascoside on MCF-7 and MDA-MB-231
Hülya Şenol, Pınar Tulay, Mahmut Çerkez Ergören, Azmi Hanoğlu, İhsan Çalış, Gamze Mocan
Abstract
Objectives: . Materials and Methods: MCF-7 and MDA-MB 231 cells were treated with verbascoside (100, 48, 25, 10, 1, 0.5, and 0.1 μM) for 24, 48, and 72 hours. Cytotoxic effect of verbascoside in MCF-7 and MDA-MB-231 cells was assessed using TEBU-BIO cell counting kit 8. Results and Conclusion: values were calculated as 0.8438, 0.5107 and 0.9203, respectively. Two-Way ANOVA multiple comparisons test results showed that 100 μM verbascoside has the highest cytotoxic effect on MDA-MB 231 BC cells after 24, 48 and 72 h of exposure.
Topics & Concepts
VerbascosideCytotoxic T cellMCF-7ChemistryIn vitroTraditional medicineCancer cellStereochemistryCancerMedicineBiochemistryInternal medicineHuman breastGlycosidePhytochemistry and Bioactive CompoundsPhytochemistry and Biological ActivitiesPhytochemical Studies and Bioactivities