Genomics of Aminoglycoside Resistance in Pseudomonas aeruginosa Bloodstream Infections at a United States Academic Hospital
Giancarlo Atassi, Rachel Medernach, Marc H. Scheetz, Sophia Nozick, Nathaniel J. Rhodes, Megan Murphy-Belcaster, Katherine R. Murphy, Arghavan Alisoltani, Egon A. Ozer, Alan R. Hauser
Abstract
genes were more common than acquisition of genes encoding aminoglycoside modifying enzymes. The whole-genome sequence of an extensively drug resistant isolate indicates that resistance mechanisms can accumulate in a single strain. Together, these results suggest that aminoglycoside resistance in P. aeruginosa remains problematic and confirm known resistance mechanisms that can be targeted for the development of novel therapeutics.
Topics & Concepts
TobramycinPseudomonas aeruginosaAmikacinAminoglycosideMicrobiologyBiologyPiperacillinColistinGentamicinCiprofloxacinAntibioticsGeneticsBacteriaAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingPneumonia and Respiratory Infections