Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis
Shaohua Hou, Xiping Yang, Tong Yu, Yuejing Yang, Quanwei Chen, Boheng Wan, Ran Wei, Yuchen Wang, Yanmin Zhang, Bo Kong, Jianhang Huang, Yadong Chen, Tao Lu, Qinghua Hu, Ding Du
Topics & Concepts
ChemistryASK1KinaseMAPK/ERK pathwayIn vivoPharmacologyColitisp38 mitogen-activated protein kinasesProtein kinase ACancer researchBiochemistryMitogen-activated protein kinase kinaseImmunologyBiologyBiotechnologyGenomics, phytochemicals, and oxidative stressRedox biology and oxidative stressSynthesis and biological activity