Molecular Pathways of Altered Brain Development in Fetuses Exposed to Hypoxia
Anna Orzeł, Katarzyna Unrug-Bielawska, Dagmara Filipecka‐Tyczka, Krzysztof Berbeka, Natalia Żeber‐Lubecka, M. Zielińska, Anna Kajdy
Abstract
Perinatal hypoxia is a major cause of neurodevelopmental impairment and subsequent motor and cognitive dysfunctions; it is associated with fetal growth restriction and uteroplacental dysfunction during pregnancy. This review aims to present the current knowledge on brain development resulting from perinatal asphyxia, including the causes, symptoms, and means of predicting the degree of brain damage. Furthermore, this review discusses the specificity of brain development in the growth-restricted fetus and how it is replicated and studied in animal models. Finally, this review aims at identifying the least understood and missing molecular pathways of abnormal brain development, especially with respect to potential treatment intervention.