Mechanochemical Syntheses of <i>N</i>-Containing Heterocycles with TosMIC
Christian Schumacher, Claude Molitor, Sabrina Smid, Khai‐Nghi Truong, Kari Rissanen, Carsten Bolm
Abstract
A mechanochemical van Leusen pyrrole synthesis with a base leads to 3,4-disubstitued pyrroles in moderate to excellent yields. The developed protocol is compatible with a range of electron-withdrawing groups and can also be applied to the synthesis of oxazoles. Attempts to mechanochemically convert the resulting pyrroles into porphyrins proved to be difficult.
Topics & Concepts
PyrroleCombinatorial chemistryChemistryBase (topology)StereochemistryOrganic chemistryMathematicsMathematical analysisPorphyrin and Phthalocyanine ChemistrySynthesis and Characterization of PyrrolesSynthesis and Reactivity of Heterocycles