Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33
Fei Zhang, Li-Man Zhou, Fan‐Dong Kong, Qing‐Yun Ma, Qingyi Xie, Jiuhui Li, Hao‐Fu Dai, Lei Guo, You‐Xing Zhao
Abstract
Five new perylenequinone derivatives, altertoxins VIII–XII (1–5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds 1–6 exhibited quorum sensing inhibitory activities against Chromobacterium violaceum CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.
Topics & Concepts
Chromobacterium violaceumCladosporiumQuorum sensingFungusMicrobiologyBiologyBacteriaBotanyGeneticsAspergillusBiofilmBacterial biofilms and quorum sensingMicrobial Metabolism and ApplicationsMicrobial Natural Products and Biosynthesis