An antibacterial and injectable calcium phosphate scaffold delivering human periodontal ligament stem cells for bone tissue engineering
Hong Chen, Hui Yang, Michael D. Weir, Abraham Schneider, Ke Ren, Negar Homayounfar, Thomas W. Oates, Ke Zhang, Jin Liu, Tao Hu, Hockin H.K. Xu
Abstract
< 0.05). In conclusion, the novel antibacterial construct with stem cell delivery had injectability, good strength, strong antibacterial effects and biocompatibility, supporting osteogenic differentiation and bone mineral synthesis of hPDLSCs. The injectable and mechanically-strong CPCC+10ORZ+hPDLSCbeads construct has great potential for treating bone infections and promoting bone regeneration.
Topics & Concepts
ScaffoldPeriodontal ligament stem cellsMesenchymal stem cellMaterials scienceStem cellPeriodontal fiberBiocompatibilityChemistryBiomedical engineeringTissue engineeringAlkaline phosphataseDentistryCell biologyMedicineBiologyBiochemistryMetallurgyEnzymePeriodontal Regeneration and TreatmentsBone Tissue Engineering MaterialsMesenchymal stem cell research