Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence
Komodo Matta, Meriem Koual, Stéphane Ploteau, Xavier Coumoul, Karine Audouze, Bruno Le Bizec, Jean‐Philippe Antignac, Germán Cano-Sancho
Abstract
BACKGROUND: -dioxin (TCDD), may play a role in the pathogenesis of endometriosis. OBJECTIVES: ) on the associations between exposure to OCCs and endometriosis-related end points. METHODS: evidence further supported the roles of the aryl hydrocarbon receptor and matrix metalloproteinases in mediating steroidogenic disruption and inflammatory responses. Estrogen interactions were found across studies and end points. CONCLUSION: evidence. Nonetheless, there is need for further research to fill in our gaps in understanding of the relationship between OCCs and their mixtures and endometriosis, beyond the prototypical TCDD. https://doi.org/10.1289/EHP8421.