HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles
Sagar R. Mudshinge, Chinmay S. Potnis, Bo Xu, Gerald B. Hammond
Abstract
We report an efficient HCl•DMPU assisted one-pot conversion of aldehydes into nitriles. The use of HCl•DMPU as both an acidic source as well as a non-nucleophilic base constitutes an environmentally mild alternative for the preparation of nitriles. Our protocol proceeds smoothly without the use of toxic reagents and metal catalysts. Diverse functionalized aromatic, aliphatic and allylic aldehydes incorporating various functional groups were successfully converted to nitriles in excellent to quantitative yields. This protocol is characterized by a broad substrate scope, mild reaction conditions, and high scalability.
Topics & Concepts
NitrileScope (computer science)ChemistrySubstrate (aquarium)Combinatorial chemistryOrganic chemistryComputer scienceGeologyOceanographyProgramming languageChemical Synthesis and AnalysisAsymmetric Hydrogenation and CatalysisChemical Synthesis and Reactions