Selective Room-Temperature Hydrogenation of Amides to Amines and Alcohols Catalyzed by a Ruthenium Pincer Complex and Mechanistic Insight
Sayan Kar, Michael Rauch, Amit Kumar, Gregory Leitus, Yehoshoa Ben‐David, David Milstein
Abstract
). The hydrogenation is catalyzed by well-defined ruthenium-PNNH pincer complexes (0.5 mol %) with potential dual modes of metal-ligand cooperation. An unusual Ru-amidate complex was formed and crystallographically characterized. Mechanistic investigations indicate that the room-temperature hydrogenation proceeds predominantly via the Ru-N amido/amine metal-ligand cooperation.
Topics & Concepts
RutheniumPincer movementChemistryCatalysisAmine gas treatingPincer ligandLigand (biochemistry)MetalNoyori asymmetric hydrogenationCombinatorial chemistryMedicinal chemistryPhotochemistryOrganic chemistryReceptorBiochemistryAsymmetric Hydrogenation and CatalysisNanomaterials for catalytic reactionsCatalysis and Hydrodesulfurization Studies