Florfenicol Enhances Colonization of a Salmonella enterica Serovar Enteritidis <i>floR</i> Mutant with Major Alterations to the Intestinal Microbiota and Metabolome in Neonatal Chickens
Xueran Mei, Boheng Ma, Xiwen Zhai, Anyun Zhang, Changwei Lei, Lei Zuo, Xin Yang, Changyu Zhou, Hongning Wang
Abstract
in the intestine. The screened target metabolites in linoleic acid metabolism affect S. Enteritidis colonization, intestinal inflammation, and intestinal barrier function. Our findings provide a better understanding of the susceptibility of animal species to Salmonella after antibiotic intervention, which may help to elucidate infection mechanisms that are important for both animal and human health.
Topics & Concepts
FlorfenicolMetabolomeSalmonella entericaBiologyMicrobiologySalmonellaGut floraSalmonella enteritidisColonizationAntibioticsColonisation resistanceResistomeEnterobacteriaceaeCecumMicrobiomeMetaboliteBacteriaIntestinal mucosaEnteritisAntibacterial agentSalmonella and Campylobacter epidemiologyAnimal Nutrition and PhysiologyAntibiotics Pharmacokinetics and Efficacy