Ferroptosis becomes immunogenic: implications for anticancer treatments
Daolin Tang, Oliver Kepp, Guido Kroemer
Abstract
Ferroptosis is an iron-dependent form of non-apoptotic cell death that has recently been attributed with antitumor immune effects. Thus, early ferroptotic cells underwent immunogenic cell death that was accompanied by the emission of damage-associated molecular patterns (DAMPs) and triggered dendritic cell maturation in vitro. Furthermore, ferroptotic cells were able to vaccinate against a rechallenge with fibrosarcoma in preclinical models.
Topics & Concepts
Immunogenic cell deathProgrammed cell deathImmune systemApoptosisCancer researchCellFibrosarcomaIn vitroApoptotic cell deathMedicineImmunologyImmunotherapyBiologyPathologyBiochemistryGeneticsFerroptosis and cancer prognosisCancer Immunotherapy and BiomarkersDrug Transport and Resistance Mechanisms