Transition-Metal-Catalyzed Cross-Coupling Reactions of Grignard Reagents
Zoltán Hell, Kinga Juhász, Ágnes Magyar
Abstract
Abstract Transition-metal-catalyzed cross-coupling of organohalides, ethers, sulfides, amines, and alcohols (and derivatives thereof) with Grignard reagents, known as the Kumada–Tamao–Corriu reaction, can be used to prepare important intermediates in the synthesis of numerous biologically active compounds. The most frequently used transition metals are nickel, palladium, and iron, but there are several examples for cross-coupling reactions catalyzed by copper, cobalt, manganese, chromium, etc. salts and complexes. The aim of this review is to summarize the most important transition-metal-catalyzed cross-coupling reactions realized in the period 2000 to 2020. 1 Introduction 2 Nickel Catalysis 3 Palladium Catalysis 4 Iron Catalysis 5 Catalysis by Other Transition Metals 5.1 Cobalt Catalysis 5.2 Copper Catalysis 5.3 Manganese Catalysis 5.4 Chromium Catalysis 6 Conclusion