Protein phosphatase 1 regulates phosphorylation of gasdermin D and pyroptosis
Ying Li, De-Bing Pu, Jian Huang, Ying Zhang, Hang Yin
Abstract
We report that phosphorylation of gasdermin D (GSDMD)-NT, cleaved by inflammatory caspases, could inhibit pyroptosis. Phosphatase 1 (PP1) is responsible for the regulation of GSDMD phosphorylation and the capacity of GSDMD to induce cell death. Our findings reveal a critical regulatory mechanism as it provides insight into pyroptosis processes.
Topics & Concepts
PyroptosisPhosphorylationCell biologyPhosphataseProgrammed cell deathChemistryCaspaseApoptosisBiologyBiochemistryInflammasome and immune disordersGout, Hyperuricemia, Uric AcidHeme Oxygenase-1 and Carbon Monoxide