An organophotocatalytic late-stage N–CH <sub>3</sub> oxidation of trialkylamines to <i>N</i> -formamides with O <sub>2</sub> in continuous flow
Mark John P. Mandigma, Jonas Žurauskas, Callum I. MacGregor, Lee J. Edwards, Ahmed Shahin, Ludwig d'Heureuse, Philip Yip, David J. S. Birch, Thomas Gruber, Jörg Heilmann, Matthew P. John, Joshua P. Barham
Abstract
An N–CH 3 -selective trialkylamine oxidation to N -formamides is reported in continuous flow using gaseous O 2 . A novel, enhanced-solubility dicyanoanthracene organophotocatalyst switched the photochemical mechanism from electron to energy transfer.
Topics & Concepts
FormamidesChemistryMedicinal chemistryOrganic chemistryCatalysisOxidative Organic Chemistry ReactionsRadical Photochemical ReactionsSynthesis and Catalytic Reactions