Differential Binding of Carbapenems with the AdeABC Efflux Pump and Modulation of the Expression of AdeB Linked to Novel Mutations within Two-Component System AdeRS in Carbapenem-Resistant Acinetobacter baumannii
Subhasree Roy, Vivek Junghare, Shanta Dutta, Saugata Hazra, Sulagna Basu
Abstract
approach was used to interpret their role in AdeABC overexpression, leading to carbapenem resistance. None of the previous studies had undertaken both these aspects simultaneously. This study analyzes the open and closed conformation of AdeB, their binding with carbapenems, and key residues involved in it. This helps in visualizing the plausible atomic level causes of pump inhibition driving the discovery of novel inhibitors.
Topics & Concepts
Acinetobacter baumanniiEffluxIn silicoCarbapenemNeisseriaceaeMicrobiologyBiologyAcinetobacterPeriplasmic spaceComputational biologyGeneticsGeneEscherichia coliAntibioticsBacteriaPseudomonas aeruginosaAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyEscherichia coli research studies