Palladium-catalyzed double strain-release (3 + 3) cycloaddition for the synthesis of vinylbicyclo[3.1.1]heptanes
Xin‐Yu Gao, Yuanjiu Xiao, Xuan Zhan, Yu-Jie Li, Kun-Ju Wang, Jian‐Jun Feng
Abstract
A protocol for synthesizing all-carbon bicyclo[3.1.1]heptanes (BCHeps) through palladium-catalyzed dipolar (3 + 3) cycloadditions of bicyclobutanes (BCBs) with vinylcyclopropanes has been developed.
Topics & Concepts
ChemistryPalladiumCycloadditionCatalysisStrain (injury)Medicinal chemistryCombinatorial chemistryOrganic chemistryInternal medicineMedicineCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Alkyne Reactions