139O Final results of the double-blind placebo (PBO)-controlled randomised phase II LOTUS trial of first-line ipatasertib (IPAT) + paclitaxel (PAC) for inoperable locally advanced/metastatic triple-negative breast cancer (mTNBC)
Rebecca Dent, Mafalda Oliveira, Steven J. Isakoff, S-A. Im, Marc Espié, Sibel Blau, Antoinette R. Tan, Cristina Saura, Matthew Wongchenko, N. Xu, Denise Bradley, S-J. Reilly, Aruna Mani, S-B. Kim
Topics & Concepts
MedicineClinical endpointInternal medicinePTENHazard ratioPopulationTriple-negative breast cancerOncologyPhases of clinical researchBreast cancerCancerChemotherapyRandomized controlled trialConfidence intervalPI3K/AKT/mTOR pathwayBiochemistryChemistryApoptosisEnvironmental healthAdvanced Breast Cancer TherapiesCancer Treatment and PharmacologyClick Chemistry and Applications