Comparative study of α-helical and β-sheet self-assembled peptide nanofiber vaccine platforms: influence of integrated T-cell epitopes
Yaoying Wu, Sean H. Kelly, Luis Sánchez-Pérez, John H. Sampson, Joel H. Collier
Abstract
) and a candidate peptide epitope for vaccination against S. aureus. Subsequent investigation indicated that Coil29 nanofibers possessed internal CD4+ T cell epitopes: whereas Q11 nanofibers required co-assembly of additional CD4+ T cell epitopes to be immunogenic, Coil29 nanofibers did not. Coil29 nanofibers also raised stronger germinal center B cell responses and follicular helper T cell (Tfh) responses relative to Q11 nanofibers, likely facilitating the improvement of the antibody response. These findings illustrate design strategies for improving humoral responses raised by self-assembled peptide nanofibers.
Topics & Concepts
EpitopeNanofiberPeptideCellChemistryT cellCell biologyImmune systemVirologyAntibodyBiologyNanotechnologyImmunologyBiochemistryMaterials scienceImmunotherapy and Immune ResponsesRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques