EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation
Lizhi Pang, Harshit Shah, Hongzhi Wang, Dan Shu, Steven Y. Qian, Venkatachalem Sathish
Abstract
. As a potential histone deacetylases inhibitor, 8-HOA subsequently inhibited cancer proliferation and induced apoptosis via suppressing YAP1/TAZ nuclear translocation and expression. Therefore, this 3WJ-RNA nanoparticle could improve the targeting and effectiveness of D5D siRNA in lung cancer therapy.
Topics & Concepts
Small interfering RNAChemistryCancer researchLipid peroxidationRNACell biologyMedicineBiologyBiochemistryGeneEnzymeRNA Interference and Gene DeliveryMicroRNA in disease regulationinterferon and immune responses