Pathologically mislocalised TDP-43 in upper motor neurons causes a die-forward spread of ALS-like pathogenic changes throughout the mouse corticomotor system
Laura A. Reale, Marcus S. Dyer, Sharn Perry, Kaylene M. Young, Tracey C. Dickson, Adele Woodhouse, Catherine A. Blizzard
Topics & Concepts
NeuroscienceMotor cortexExcitatory postsynaptic potentialInhibitory postsynaptic potentialMotor neuronSpinal cordLumbarPrimary motor cortexBiologyMotor systemLumbar Spinal CordPsychologyAnatomyStimulationAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchParkinson's Disease Mechanisms and Treatments